Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening
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چکیده
منابع مشابه
Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening
BACKGROUND Hypocatabolism of the amyloid beta-protein (Abeta) by insulin-degrading enzyme (IDE) is implicated in the pathogenesis of Alzheimer disease (AD), making pharmacological activation of IDE an attractive therapeutic strategy. However, it has not been established whether the proteolytic activity of IDE can be enhanced by drug-like compounds. METHODOLOGY/PRINCIPAL FINDINGS Based on the ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0005274